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au:Martinez-Moreno, Alejandra
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1.
Variability in the virulence of specific Mycobacterium tuberculosis clinical isolates alters the capacity of human dendritic cells to signal for T cells
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Ramos-Martinez, Ana Gabriela
; Valtierra-Alvarado, Monica Alejandra
; Garcia-Hernandez, Mariana Haydee
; Hernandez-Pando, Rogelio
; Castañeda-Delgado, Julio Enrique
; Cougoule, Céline
; Rivas-Santiago, Bruno
; Neyrolles, Olivier
; Enciso-Moreno, Jose Antonio
; Lugo-Villarino, Geanncarlo
; Serrano, Carmen Judith
.
BACKGROUND Once in the pulmonary alveoli, Mycobacterium tuberculosis (Mtb) enters into contact with alveolar macrophages and dendritic cells (DCs). DCs represent the link between the innate and adaptive immune system owing to their capacity to be both a sentinel and an orchestrator of the antigen-specific immune responses against Mtb. The effect that the virulence of Mtb has on the interaction between the bacilli and human DCs has not been fully explored. OBJECTIVE To evaluate the effect of Mtb virulence on human monocyte-derived DCs. METHODS We exposed human monocyte-derived DCs to Mtb clinical strains (isolated from an epidemiological Mtb diversity study in Mexico) bearing different degrees of virulence and evaluated the capacity of DCs to internalise the bacilli, control intracellular growth, engage cell death pathways, express markers for activation and antigen presentation, and expand to stimulate autologous CD4+ T cells proliferation. FINDINGS In the case of the hypervirulent Mtb strain (Phenotype 1, strain 9005186, lineage 3), we report that DCs internalise and neutralise intracellular growth of the bacilli, undergo low rates of apoptosis, and contribute poorly to T-cell expansion, as compared to the H37Rv reference strain. In the case of the hypovirulent Mtb strain (Phenotype 4, strain 9985449, lineage 4), although DCs internalise and preclude proliferation of the bacilli, the DCs also display a high level of apoptosis, massive levels of apoptosis that prevent them from maintaining autologous CD4+ T cells in a co-culture system, as compared to H37Rv. MAIN CONCLUSIONS Our findings suggest that variability in virulence among Mtb clinical strains affects the capacity of DCs to respond to pathogenic challenge and mount an immune response against it, highlighting important parallels to studies previously done in mouse models.
https://doi.org/10.1590/0074-02760190102
925 downloads
2.
Type-2 diabetes alters the basal phenotype of human macrophages and diminishes their capacity to respond, internalise, and control Mycobacterium tuberculosis
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Lopez-Lopez, Nallely
; Martinez, Ana Gabriela Ramos
; Garcia-Hernandez, Mariana Haydee
; Hernandez-Pando, Rogelio
; Castañeda-Delgado, Julio Enrique
; Lugo-Villarino, Geanncarlo
; Cougoule, Céline
; Neyrolles, Olivier
; Rivas-Santiago, Bruno
; Valtierra-Alvarado, Monica Alejandra
; Rubio-Caceres, Marisela
; Enciso-Moreno, Jose Antonio
; Serrano, Carmen Judith
.
BACKGROUND Type 2 diabetes (T2D) is a risk factor for the development of tuberculosis (TB), although the associated mechanisms are not known. OBJECTIVES To study the association between T2D and the basal phenotype of macrophages, and their immune response to Mycobacterium tuberculosis (Mtb) infection. METHODS We evaluated the influence of T2D on the response of monocyte-derived macrophages (MDM) to Mtb in patients with T2D (n = 10) compared to healthy subjects (n = 9), before and after infection with Mtb clinical isolates bearing different degrees of virulence. The levels of cell surface markers for activation secreted cytokines and chemokines, bacterial association, and intracellular bacterial growth were evaluated. FINDINGS The expression levels of HLA-DR, CD80, and CD86 were low while those of of PD-L1 were high in uninfected MDMs derived from patients with diabetes; as a result of Mtb infection, changes were only observed in the expression levels of PD-L1. The levels of cytokines (e.g., IL-6, IL-1β, IL-10, and IL-12) and chemokines (e.g., MCP-1, MIG, and RANTES) are perturbed in MDMs derived from patients with diabetes, both before infection and in response to Mtb infection. In response to the more virulent Mtb strains, the levels of association and bacterial clearance were diminished in MDMs derived from patients with diabetes. CONCLUSIONS T2D affects the basal activation state of the macrophages and its capacity to respond and control Mtb infection.
https://doi.org/10.1590/0074-02760170326
2011 downloads
3.
Trabajos de investigación presentados en el L Congreso Mexicano de Anestesiología: Chihuahua 2017. México
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Ríos Medrano, Alea Fernanda
; Herrero Trujillano, Manuel
; Robles López, Maria Decire
; Rodríguez Barajas, Ruben
; Gutiérrez-Martínez, Paola Virginia
; Ramírez-Gómez, Melba
; Olvera-Hernández, Jesus Arnoldo
; Márquez Noyola, Elizabeth Alicia
; Almonte de León, Héctor
; Hernández Mancilla, Arturo
; Castro Salinas, José Ernesto
; Medrano-Duarte, Olga Abigahil
; Ramírez-Mendoza, Karla
; Rodriguez-Nieves, Georgina Monserrat
; Pareces Ríos, Adriana
; Ruiz-Rubio, Yolanda
; Hernández-Santiago, María Guadalupe
; Ramírez Mendoza, Karla
; Medrano Duarte, Olga Abigahil
; Martínez-Alpuche, Rocío Adriana
; Valenzuela-Priego, Francisco
; Álvarez-Santiago, José Heriberto
; Lugo-Rodríguez, Julian
; Betancourt-Sandoval, Alonso
; Prince-Angulo, Silvia Annel
; Martínez-Felix, Israel
; Salazar-Castro, Laura
; Espinazo-Quintero, Erendira
; Otañez, Monica Thalia
; Priego, Gloria
; Alzate, Ana Lizette
; Salazar, Laura Elena
; Nieblas, Mariela
; Martinez, Israel
; Alvarez-Betancourt, Ana Elsa
; Sánchez-Hernández, Eloy
; Romo-Serrano, Erika
; Rodríguez-Jauregui, Adriana
; Díaz-Aceves, Erica Raquel
; Arteaga-Trejo, Jaime
; Rodríguez-Jáuregui, Adriana
; Robles-Lopéz, María Decire
; Ibarra-González, María Livier
; Alvarez-Betancourt, Ana Elsa
; Díaz-Aceves, Erica Raquel
; Arteaga-Trejo, Jaime
; Santana-Sonora, Beatriz Alejandra
; Prince-Angulo, Silvia Annel
; Sandoval-Rivera, Arturo Guadalupe
; Camacho-López, Jesús Erick
; Alzate-Moctezuma, Ana Lizette
; Valencia-Echávarri, Andrea
; Canales-Bonilla, Carlos Patricio
; Ramos-Hernández, Julia Demetria
; Flores-Posada, Jesus Jonathan
; Muñoz Garcia, Aleyda
; Osorio Santiago, Maria Areli
; Lopez Cartita, Victor
; Ortega, Julio
; Fuentes García, Víctor E
; Moyao García, Diana
; Villars Zamora, Elvia Gabriela
; Prince Angulo, Silvia Annel
; Gerardo Angulo, Alma Ruth
; Martinez Felix, Israel
; Ayala Camargo, Yuridia
; Esquer de la Rosa, Jaquelyn Roxana
; Trapaga Millares, Yazmin
; Sánchez León, Claudia Elena
; Vásquez Puente, Felipe
; Rojo Medina, Victor Javier
; Urias Romo de vivar, Emma Gabriela
; Prince Angulo, Silvia Annel
; Ojeda Ramos, Joel
; Caceres Figueroa, Leonardo Andres
; Martinez Reyes, Maria Fernanda
; Contreras Ramírez, Nathalie
; Martínez Barreto, Nelly
; Ruelas León, Berenice
; Reyes Salgado, Karla
; Ruvalcaba Sánchez, Rafael
; Núñez Valencia, Carolina
; Escamilla Asiain, Gabriela
; Carranza-Cortés, José Luis
; Puga-Flores, Eva del Carmen
; Jiménez-Cardona, María Beatriz
; Puga-García, Diana Marisol
; Alcaraz-Ramos, Rosina
; Martinez-Delgado, Olinda
; Zamudio-Gracia, Carlos Amador
; Mireles Vega, Elizabeth
; Hernández López, Clara
; Ceballos Niño, Jose Luis
; Carreño Caballero, Jessica
; Montiel Jarquín, Álvaro José
; López García, Ingrid
; Serrano Cuevas, Beatriz
; Martinez Marin, Dolores Guillermina
; Díaz-Aceves, Erica Raquel
; Romo-Serrano, Erika
; Campechanos-Asencio, María de los Ángeles
; Rodríguez-Jáuregui, Adriana
; Betancourt-Álvarez, Ana Elsa
; Arteaga-Trejo, Jaime
; Arteaga-Trejo, Jaime
; Romo-Serrano, Erika
; Rios-Navarro, Ramón Alejandro
; Rodriguez-Jauregui, Adriana
; Alvarez-Betancourt, Ana Elsa
; Diaz Aceves, Érica Raquel
; Calleja-Zenteno, Liliana
; Fernández-Vázquez, María Urbelina
; Carreño-Caballero, Jessica
; Serrano Cuevas, Beatriz
; Montiel Jarquín, Álvaro José
; Carreño- Caballero, Jessica
; Cortes- Pineda, Claudia
; Fernández-Vázquez, María Urbelina
; Hernández-Domínguez, Juan
; Serrano-Cuevas, Beatriz
; Ruiz- Luna, Mayra
; Gómez-Moreno, Julieta Berenice
; Hernández-Santiago, Maria Guadalupe
; Ruiz-Rubio, Yolanda
; Ruiz-Serrano, Ana Cristina
; Medina-Flores, Aleida
; Sánchez Torres, Claudia
; Osorio Santiago, María Areli
; Lee, Angel
; Correa-Ovis, Jose Francisco
; Priego-Martínez, Luis Alberto
; Valencia-Carrillo, Miguel
; Sánchez-Arteaga, Sofia
; Cruz-Márquez, Abraham Josué
; Duran-Zamora, Karina Aurora
; Corral-Guerrero, Sergio Francisco
; Arce Bojorquez, Brisceyda
; Medina, Francisco
; Felix, Pavel
; Estrada, Haydeé Gloria
; González-Herrera, Francisco Javier
; Zepeda Olivera, Silvia
; Pablo-Yañez, Julio Cesar
; Colores Velazquez, Julio Cesar
; Calva Maldonado, Miguel
; Veyna Rocha, Sissy Barubi
; Veyna Rocha, Abraham Irishd
; Rodríguez-Rodríguez, María Guadalupe
; Castillo- Rodriguez, Juan Orlando
; Martínez-Figueroa, Brenda Paola
; Romero Guillén, Lorena Priscila
; Pavía Vega, Susy Sáez
; Jiménez Siles, María Eugenia
; Hurtado Reyes, Ignacio Carlos
; Rojas Zarco, Eder Marcelo
; Sánchez Tapia, Mario Alberto
; Villicaña-Ayala, Carolina
; Díaz-Aguilar, Marco Antonio
; Apolinar Jiménez, Evelia
; García-Parra Pérez, Paola Carolina
; García-Parra Pérez, Natalia Cristina
; Yee-Rendón, Zumey
; Valle-Leal, Jaime Guadalupe
; Reyes-Jiménez, Gerardo Antonio
; Ortiz-Magallanes, Elías
; Sanchez-Aguilar, Maricela
; Mota-Figueroa, Roanne Patrician
; Espinosa-Tadeo, Aldo Ernesto
; Díaz-Hernández, Alejandro Eduardo
; Cendón-Ortega, María Mercedes
; Ortega-Ponce, Fabiola Estela Elizabeth
; Romero-Guillen, Lorena Priscila
; Cruz Castañedo, Greta
; Constantino-Rivera, Luis Armando
; Gordillo-Paniagua, Jorge Alberto
; Contreras-Ramírez, Nathalie
; Bernal-Zambrano, Luis Omar
; Flores-Alvarado, Rosa María
; Ferrera-Sarquís, María Aurora
; Espino Vega, Ana Frain
; Guillen-Narváez, María del Rocio
; López-García, Rocío Angélica
; Martínez-Sánchez, Angélica
; Huerta-Beltrán, Juana Geraldine
; Gómez-Rojas, Juan Pablo
; Rivera-Ruiz, Rodolfo Eduardo
; Ramírez Reyes, Liliana Georgina
; Muñoz Martínez, Raúl
; Martínez-Morales, Nayeli Noemi
; Mariscal-Cervantes, Beatriz
; Chávez-Barragán, Oscar Fernando
; Barrera-de León, Juan Carlos
; Carrillo-Guerra, Valentin
; Huitrón-Hernández, José Alonso
; De la Rosa-Fabián, Viviana Marysela
; Zertuche-Méndez, David Ricardo
; Riquelme Holguin, Karla Talia
; Gutierrez Beltran, Maria del Refugio
; Martinez-Tapia, Maria Elena
; Amezquita Esparza, Monica
; Portillo Villalobos, Samantha
; Díaz Solís, Erick Iván
; Estrada Utrera, Maria Sandra
; Islas Ruz, Félix Gilberto
; Pérez Díaz, Roberto
; Chávez-Contreras, Sara Idali
; Zepeda Olivera, Silvia
; Calva-Maldonado, Miguel
; Fragoso-Avilés, Fabían
; Rosa-Moya, Griselda de la
; Ávila-López, Armando
; López Castruita, Victor Manuel
; Manrique Carmona, Luisa Piedad
; Ramírez- Martínez, Elizabeth
; Rojas-Peñaloza, Janeth
; López-Gómez, Antonio
; Veyna Rocha, Abraham Irishd
; Veyna Rocha, Sissy Barubi
; Torres Hernández, Rosa
; Aleman-Ortega, Cristina
; Guevara-Pérez, Alejandra
; Castillo Gamez, Tobias Francisco
; Gutierrez Beltran, María del Refugio
; Martínez Tapia, María Elena
; Alanis Uribe, Karla
; Guerrero Morales, Fernando
; Molina Rodríguez, Gloria
; Gómez Cruz, José Roberto
; Tapia Castro, Gabriela
; Ley, Marcial Luis
; Castro Ortega, Julio
; Martínez, Leo Bruno
; Portugal Moreno, Víctor Hugo
; García Cabello, Luis Manuel
.
15352 downloads
4.
Sobrecarga del cuidador principal como factor de riesgo para caídas en pacientes geriátricos
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1128 downloads
5.
Sobrecarga del cuidador principal como factor de riesgo para caídas en pacientes geriátricos
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1534 downloads
6.
ENCOMS: Argentinian survey in cost of illness and unmet needs in multiple sclerosis
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Ysrraelit, Celica
; Caceres, Fernando
; Villa, Andres
; Marcilla, Marcela Parada
; Blanche, Jorge
; Burgos, Marcos
; Parera, Ignacio Casas
; Colombo, Oscar
; Crespo, Ernesto
; Deri, Norma
; Labal, Patricio
; Maluendez, Monica
; Martinez, Alejandra
; Melcon, Mario
; Nofal, Pedro
; Reich, Edgardo
; Sinay, Vladimiro
; Tarulla, Adriana
; Vetere, Santiago
; Barboza, Andres
; Rey, Roberto
; Moreno, Margarita
; Bacile, Alejandra
; Rojas, Juan I.
; Kuperman, Gaston
; Resk, Mercedes
; Seifer, Gustavo
; Machinicki, Gerardo
; Cuneo, Jorge
.
The objective of the study was to assess the cost of multiple sclerosis (MS) patients in Argentina categorized by disease severity using a societal perspective.Method:Cross-sectional study including MS patients from 21 MS centers in 12 cities of Argentina. Patients were stratified by disease severity using the expanded disability status scale (EDSS) (group 1 with EDSS score between 0 and 3; group 2 with EDSS >3 and <7; group 3 with EDSS ≥7). Direct and indirect costs were analyzed for the second quarter of 2012 from public sources and converted to US Dollars.Results:266 patients were included. Mean annual cost per MS patient was USD 36,025 (95%CI 31,985-38,068) for patients with an EDSS between 0-3; USD 40,705 (95%CI 37,199-46,300) for patients with EDSS >3 and <7, and USD 50,712 (95%CI 47,825-62,104) for patients with EDSS ≥7.Conclusions:This is the first Argentine study evaluating the costs of MS considering disease severity.
El objetivo del estudio fue evaluar el costo de los pacientes con esclerosis múltiple (EM) en Argentina categorizados por severidad de la enfermedad.Método:Estudio de corte transversal que incluyó pacientes con EM en 12 ciudades de Argentina. Los pacientes se estratificaron según expanded disability status scale (EDSS) (grupo 1 EDSS entre 0 y 3; grupo 2 EDDS >3 y <7; grupo 3 EDSS ≥7). Los costos directos e indirectos fueron analizados para el segundo trimestre de 2012 y convertidos a dólares estadounidenses.Resultados:266 pacientes fueron incluidos. El coste medio anual por paciente con EM fue de USD 36,025 (31,985-38,068 IC95%) para los pacientes con un EDSS entre 0-3; USD 40,705 (37,199-46,300 IC95%) para los pacientes con EDSS >3 y <7 y USD 50,712 (47,825-62,104 IC95%) para los pacientes con EDSS ≥7.Conclusiones:Primer estudio argentino evaluar los costes de la EM considerado la gravedad de la enfermedad.
https://doi.org/10.1590/0004-282X20140016
5177 downloads
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